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  Section: General Biotechnology / Genes & Genetic Engineering
 
 
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Genetic Engineering for Human Welfare

 
     
 

Vaccines for Rabies Virus (RV)

RV causes hydrophobia in animals and human in many countries like. South America, Africa, Asia (including India and Pakistan). Researches are being done to synthesize vaccines by inducing genetically engineered E. coli cells. However, attempt has been made to isolate mRNA encoding viral protein from RV infected cells. The genes coding for the production of rabies virus glycoprotein coat has been successfully transferred to E. coli. This is the first step towards the production of antirabies virus vaccines as this glycoprotein stimulates antibody production in diseased animals. In 1984, Wistar Institute in Philadelphia developed a new genetically engineered vaccinia virus by inserting a small piece of foreign DNA. The genetically engineered virus synthesized antirabies vaccines for animals. The recombinant vaccinia virus did not cause rabies in those animals that received rabies genome but encoded antigenic molecules and activated the immune system against rabies infection. This new vaccine can be administered orally in animals, and could be decreased the risk of human death due to bites of animals receiving rabies virus (Peters, 1993)
 

Content

Cloned genes and production of chemicals

 

Human peptide hormone genes

 

 

Insulines

 

 

Somatotropin

 

 

Somatostatin

 

 

b-endorphin

 

Human interferon genes

 

Genes for vaccines

 

 

Vaccine for hepatitis-B virus

 

 

Vaccines for Rabies virus

 

 

Vaccines for poliovirus

 

 

Vaccine for foot and mouth disease virus

 

 

Vaccines for small pox virus

 

 

Malaria vaccines

 

 

DNA vaccines

 

Genes associated with genetic diseases

 

 

Phenylketonuria

 

 

Urokinase

 

 

Thalassaemia

 

 

Hemophilia

 

Enzyme engineering

 

Commercial chemicals

Prevention, diagnosis and cure of diseases

 

Prevention of diseases

 

Diagnosis of diseases

 

 

Parasitic diseases

 

 

Monoclonal antibodies

 

 

Antenatal diagnosis

 

Gene therapy

 

 

Types of gene therapy

 

 

Methods of gene therapy

 

 

Success of gene therapy

 

 

Potential of gene delivering system

 

 

Future needs of gene therapy in India

DNA profiling (fingerprinting)

 

Methods of DNA profiling

 

Application of DNA profiling

 

 

Genetic databank

 

 

Reuniting the lost children

 

 

Solving disputed problems of parentage, identity of criminals, rapists, etc

 

 

Immigrant dispute

 

Hurdles of DNA profiling

Animal and plant improvement

 

Transgenic Farm Animals

 

Crop Improvements

 

 

Transgenic plants

 

 

Nif gene transfer

 

 

Phaseolin gene transfer

 

 

Conversion of C3 plants to C4 plants

 

 

Herbicide resistant plants

 

 

Insect pest resistant plants

 

 

Plant improvement through genetic transformation

 

Crop Protection

 

 

Use of antagonists

 

 

Use of insecticides

Abatement of pollution

 
     
 
 
     



     
 
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