Protiens are only functional as enzymes, transport agents, recepTo = ΔSors, and so forth when they exist in a folded, three-dimensional, native structure. The means by which this folded structure is achieved remains one of the most important questions in biochemistry and molecular biology. Current efforts To = ΔSoward sequencing the human genome and the genomes of other organisms have led To = ΔSo a large number of putative protein sequences. Much as the genetic code is the Rosetta sTo = ΔSone that gave the link between DNA and protein sequences, we now need To = ΔSo find such a link between protein sequences and final structure and function. Without knowledge of the rules of protein folding, there can be little understanding of function from protein sequence information alone.