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  Section: Genetics » Organization of Genetic Material » Split, Overlapping & Pseudogenes
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Split genes in fungal mitochondria

Organization of Genetic Material 3.  Split Genes, Overlapping Genes and Pseudogenes
Split genes or interrupted genes 
Discovery and nature of split genes
R-loop mapping and restriction mapping of interrupted genes
Structure of chicken ovalbumin split gene
Split genes in fungal mitochondria
Split genes in chloroplasts
Intron of one gene may contain exon of another gene
Exon sequences are conserved, but intron sequences vary
Introns with coding sequences
Overlapping genes
Promiscuous DNA
Split genes in fungal mitochondria
Split genes are also found in mitochondria. Introns of these split genes in fungal mitochondria are classified into group I and group II introns on the basis of their internal organization. (i) Group I introns, which are found in majority of the fungal mitochondrial split genes, do not carry any conserved sequences at intron-exon junctions, but carry internally a short conserved sequence called 'internal guide sequence' By internal pairing, this guide sequence brings the two intron-exon junctions together and help in splicing out the introns (see Expression of Gene : Protein Synthesis 3.  RNA Processing (RNA Splicing, RNA Editing and Ribozymes) for details). These group I introns are also found in the nuclear genes coding for rRNA in Tctrahymena (a ciliate) and Physarutn (a slime mold). Features similar to those of group I introns are also found in introns of phage T4 genes, (ii) Group II introns resemble nuclear genes and have consensus sequences (GT and APy) and a branch sequence that resembles the TACTAAC box. These introns are excised as lariats (see Expression of Gene : Protein Synthesis 3.  RNA Processing (RNA Splicing, RNA Editing and Ribozymes)).


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